Research opens doors to the future of cancer treatment

We use clinical trials to find better ways to treat cancer. Your participation in a study can give you early access to groundbreaking drugs or therapies that most cancer centers can't offer.
 
Dozens of clinical studies are currently underway at Goshen Center for Cancer Care. Use our list of cancer types to search for studies that are open for enrollment by qualified patients.
 
Descriptions about each study explain the purpose of the trial, who is eligible to participate and how to get more information.
 
ClinicalTrials.gov maintains a complete list of current clinical trials around the world.

Cancer care close to home

Our dedicated team of oncologists and cancer care specialists at Goshen Center for Cancer Care offer world-renowned care with a hometown touch. Your team of cancer experts is prepared to stand beside you every step of the way, from diagnosis and treatment to recovery and beyond.
 
You are at the center of everything we do while you are in our care. Our integrative approach means we design a treatment program specifically for you and your needs. It's how we empower you when you need it most.
 
We believe a second opinion about your diagnosis can be life changing. A thorough evaluation may help provide a clear path for your treatment and give you peace of mind.

Get a Second Opinion

We can help

Find out if a clinical trial is right for you. Talk with our oncology experts about studies that offer patients early access to drugs approved by the Food and Drug Administration.
 
Goshen Center for Cancer Care
200 High Park Avenue
Goshen IN 46526
(888) 492-HOPE
gcccresearch@goshenhealth.com

  • Bladder Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

  • Colon and Rectum Cancer

    Colon: NRG-GI005
    Sponsor: NRG Oncology
    Study: Colon: NRG-GI005
    Cancer stage: Stage IIA

    Description:

    Inclusions: 

    • Stage IIA adenocarcinoma of the colon with at least 12 lymph nodes examined at the time of surgical resection
    • Appropriate for active surveillance (i.e., no adjuvant chemotherapy) at the discretion of and as documented by the evaluating oncologist based on current practice patterns
    • The distal extent of the tumor must be >= 12 cm from the anal verge on pre-surgical endoscopy 
    • ECOG performance status of 0 or 1

    Exclusions: 

    • Colon cancer histology other than adenocarcinoma (i.e., neuroendocrine carcinoma, sarcoma, lymphoma, squamous cell carcinoma, etc.)
    • Pathologic, clinical, or radiologic evidence of metastatic disease

    Prior treatment: 

    • Yes, prior surgery is required

    Purpose: 

    • This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery

    Basic qualifications:

    • Stage IIA adenocarcinoma of the colon with at least 12 lymph nodes examined at the time of surgical resection
    • Appropriate for active surveillance (i.e., no adjuvant chemotherapy) at the discretion of and as documented by the evaluating oncologist based on current practice patterns
  • Esophageal and Stomach Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

  • Gynecologic Cancer

    Gynecologic: NRG-GY019
    Sponsor: NRG Oncology
    Study: GY019
    Cancer stage: Stage II-IV

    Description: A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum (NCT#04095364)

    Inclusions:

    • Newly diagnosed Stage II-IV ovarian cancer
    • Must have undergone an attempt at maximal upfront cytoreductive surgery and bilateral salpingo-oophorectomy

    Exclusions:

    • May not have received neoadjuvant chemotherapy or radiotherapy and no previous hormonal therapy for the treatment of this disease

    Prior treatment:

    • None

    Purpose:

    • To examine if letrozole monotherapy/maintenance (L/L) is non-inferior to IV paclitaxel/carboplatin and maintenance letrozole (CT/L) with respect to PFS in women with stage II-IV primary low-grade serous carcinoma of the ovary or peritoneum after primary surgical cytoreduction.

    Basic qualifications:

    • Same as inclusion criteria
  • Kidney Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

  • Lung Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

    Lung: A151216 (ALCHEMIST Screen)
    Sponsor: Alliance
    Study: Lung: A151216 (ALCHEMIST Screen)
    Cancer stage: Resectable NSCLC IB-IIIA

    Description:

    Inclusions: 

    • For post-surgical patients
    • Completely resected non-small cell lung cancer. Patients with squamous cell carcinoma are eligible.
    • Pathologic stage IIIA, II or IB (defined as size ≥4 cm) For all patients • ECOG Performance Status 0-1 • Age ≥ 18 years
    • No prior or concurrent malignancies within 5 years, except non-melanoma skin carcinoma or in situ carcinomas. A secondary primary lung cancer is considered a concurrent malignancy and would make a patient ineligible for A151216.• No prior treatment with agents targeting EGFR mutation, ALK rearrangement, and PD-1/PD-L1/CTLA-4.
    • Patients who have had local genotyping are eligible, regardless of the local result.
    • No patients with recurrence of lung cancer after prior resection. Patient Registration Eligibility Criteria
    • Pathologic stage IIIA, II, or large IB (defined as size ≥ 4cm)
    • Tissue available for the required analyses (either clinical tissue block or slides and scrolls)
    • In order to allow for time for central genotyping and eligibility for the ALCHEMIST treatment trial, patients must register within the following eligibility windows, depending on the adjuvant treatment approach:
    1. If no adjuvant therapy, register patient within 75 days following surgery.
    2. If adjuvant chemotherapy only, register patient within 225 days following surgery.
    3. If adjuvant chemotherapy and radiation, register patient within 285 days following surgery.

    Exclusions: 

    Prior treatment: 

    • No patients who have received neoadjuvant therapy (chemo- or radio-therapy) for this lung cancer.

    Purpose: 

    • This research trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been removed or will be removed by surgery.

    Basic qualifications:

    • Completely resected (resectable) non-small cell lung cancer.
    • Patients with squamous cell carcinoma are eligible.

    Lung: LungMAP Screening
    Sponsor: SWOG
    Study: Lung: LungMAP Screening
    Cancer stage: Stage IV NSCLC

    Description:

    Inclusions: 

    • Stage IV or recurrent NSCLC
    • Must have received at least one line of systemic therapy for any stage of disease (Stages I-IV) and must have progressed during or following their most recent line of therapy
    • Must have adequate tissue available and a sample submitted to Foundation Medicine for biomarker profiling
    • Must be willing to provide prior smoking history

    Exclusions: 

    • Patients with known EGFR sensitizing mutations, EGFR T790M mutation, ALK gene fusion, ROS 1 gene rearrangement, or BRAF V600E mutation are not eligible

    Prior treatment: 

    • Prior treatment is required: must have received at least one line of systemic therapy 

    Purpose: 

    • Pre-screening-to-sub-study assignment will be measured among pre-screened patients and the proportion of patients assigned to a sub-study

    Basic qualifications 

    • Stage IV or recurrent NSCLC
    • Must have received at least one line of systemic therapy for any stage of disease (Stages I-IV) and must have progressed during or following their most recent line of therapy

    Lung: M14-239
    Sponsor: AbbVie
    Study: Lung: M14-239
    Cancer stage: NSCLC

    Description: Lung Luminosity pamphlet

    Inclusions:   

    •   Subjects must have locally advanced or metastatic NSCLC
    •   Subjects must have c-Met+NSCLC
    •   Subjects have an ECOG Performance Status of 0 or 1  
    •   Subjects must have received no more than 2 lines of prior systemic chemotherapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the metastatic setting

    Exclusions: 

    • Subjects must not have a history of interstitial lung disease or pneumonitis      

    Prior treatment: 

    • Subjects must have received no more than 2 lines of prior systemic chemotherapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the metastatic setting   

    Purpose: 

    • The primary objective is to determine the overall response rate (ORR) of telisotuzumab vedotin in subjects with c-Met+ NSCLC.

    Basic qualifications: 

    •   Subjects must have locally advanced or metastatic NSCLC
    •   Subjects must have c-Met+NSCLC

    Lung: JZP712-402
    Sponsor: Jazz Pharmaceuticals
    Study: Lung: JZP712-402
    Cancer stage: Extensive Stage Small Cell Lung Cancer

    Description: Phase IV Observational Study to Collect Safety and Outcome Data in Adult Patients with Extensive Stage Small Cell Lung Cancer (SCLC) Receiving Zepzelca

    Inclusions: 

    • Patient has initiated or will be receiving Zepzelca treatment in line with the Zepzelca US prescribing information

    Exclusions: 

    • Patients who discontinued a prior Zepzelca treatment due to adverse events

    Prior treatment: 

    Purpose: 

    • This is a phase IV observational study designed to collect data on treatment with Zepzelca

    Basic qualifications:

    • The treatment decision, decision to initiate Zepzelca, and overall patient management is entirely at the investigators’ discretion and should not be impacted by the conduct of this study

    Lung: E4512 (ALCHEMIST - ALK)
    Sponsor: ECOG-ACRIN
    Study: Lung: E4512 (ALCHEMIST - ALK)
    Cancer stage: Resectable NSCLC IB-IIIA

    Description:

    Inclusions: 

    • Age ≥ 18 years.
    • Patients must have undergone complete surgical resection of their stage IB (≥ 4 cm), II, or non-squamous IIIA NSCLC and have had negative margins. N3 disease is not allowed.
    • ECOG performance status 0 or 1.
    • Positive for translocation or inversion events involving the ALK gene locus (e.g. resulting in EML4-ALK fusion) as determined by the Vysis Break Point FISH assay and defined by an increase in the distance between 5’ and 3’ ALK probes or the loss of the 5’ probe.
    • No known interstitial fibrosis or interstitial lung disease.
    • No use of medications, herbals, or foods that are known potent CYP3A4 inhibitors or inducers.
    • Patients must not have any history of cancer within 5 years from randomization, with the exception of in-situ carcinomas and non-melanoma skin cancer.

    Exclusions: 

    Prior treatment: 

    • Adjuvant treatment is allowed. No prior treatment with crizotinib or another ALK inhibitor.

    Purpose: 

    • This randomized phase III trial studies how well crizotinib works and compares it to placebo in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation.

    Basic qualifications:

    • Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior to randomization.

    Lung: MK3475-867
    Sponsor: Merck
    Study: Lung: MK3475-867
    Cancer stage: Stages I or IIA

    Description: A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA NSCLC (KEYNOTE-867) Trial brochure

    Inclusions: 

    • Has NSCLC diagnosed by histology or cytology and confirmed as Stage I or IIA                                                            
    • Cannot undergo thoracic surgery due to existing medical illness  
    • Is able to receive SBRT
    • Has an ECOG Performance Status of 0, 1, or 2

    Exclusions: 

    • Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor                                                                                                                               
    • Has received prior radiotherapy to the thorax, including radiotherapy to the esophagus, mediastinum, or breast.

    Prior treatment: 

    • No prior therapy with an anti-PD-1, anti-PD-L1, anti PD-L2 agent or CTLA-4  

    Purpose:  

    • To compare the Event Free Survival following administration of Stereotactic Body Radiotherapy plus pembrolizumab versus Stereotactic Body Radiotherapy plus placebo  

    Basic qualifications:

    • Has NSCLC diagnosed by histology or cytology and confirmed as Stage I or IIA                                                            
    • Cannot undergo thoracic surgery due to existing medical illness  

    Lung: 849-007
    Sponsor: Mirati
    Study: Lung: 849-007
    Cancer stage: Metastatic or unresectable NSCLC

    Description: Krystal-7 study flyer

    Inclusions: 

    • NSCLC (squamous or nonsquamous) with KRAS G12C mutation
    • Unresectable or metastatic disease
    • Not a candidate for chemoradiation for locally advanced disease

    Exclusions: 

    • Prior systemic treatment for locally advanced or metastatic NSCLC

    Prior treatment: 

    • No prior treatment allowed

    Purpose: 

    • To evaluate the clinical activity of the MRTX849 study drug in combination with pembrolizumab administered in the first-line treatment setting to patients having NSCLC with KRAS G12C mutation

    Basic qualifications: 

    • NSCLC (squamous or nonsquamous) with KRAS G12C mutation
    • Unresectable or metastatic disease

    Lung: 849-012
    Sponsor: Mirati
    Study: Lung: 849-012
    Cancer stage: Advanced or metastatic disease

    Description: A Randomized Phase 3 Study of MRTX849 versus Docetaxel in Patients with Previously Treated Non-Small Cell Lung Cancer with KRAS G12C Mutation. Krystal-7 study flyer

    Inclusions: 

    • NSCLC with KRAS G12C mutation
    • Receipt of prior treatment with a platinum and immune checkpoint inhibitor containing regimen for advanced or metastatic disease

    Exclusions: 

    • Active brain metastases
    • Prior treatment with an agent targeting KRAS G12C

    Prior treatment: 

    • Prior treatment with an immune checkpoint inhibitor and a platinum containing regimen required

    Purpose: 

    • To compare the efficacy of MRTX849 versus docetaxel in patients with NSCLC with KRAS G12C mutation

    Basic qualifications:

    • NSCLC with KRAS G12C mutation 
    • Receipt of prior treatment with a platinum containing regimen and an immune checkpoint inhibitor

    Lung: BGB-317-A1217-302
    Sponsor: BeiGene
    Study: Lung: BGB-317-A1217-302
    Cancer stage: Previously untreated locally advanced unresectable or metastatic Non-Small Cell Lung Cancer

    Description: A Phase 3, Randomized, Double-Blind Study of BGB-A1217, an Anti-TIGIT Antibody, in Combination With Tislelizumab Compared to Pembrolizumab in Patients With Previously Untreated, PD-L1-Selected, and Locally Advanced, Unresectable, or Metastatic Non -Small Cell Lung Cancer

    Inclusions: 

    • NSCLC that is not eligibel for curative surgery and/or definitive radiotherapy with or without chemoradiotherapy
    • No prior systemic treatment for metastatic NSCLC
    • Tumors with PD-L1 expression as centrally determined
    • Measurable lesions

    Exclusions: 

    • Known senstizing mutation in the EGFR gene or an ALK fusion oncogene
    • Active leptomeningeal disease or uncontrolled, untreated brain metastasis

    Prior treatment: 

    • No prior systemic treatment for metastatic NSCLC

    Purpose: 

    • This study compares progression-free survival and overall survival between arm A (BGB-A1217 in combination with Tislelizumab) and arm B (Pembrolizumab followed by placebo)

    Basic qualifications:

  • Lymphoma and Blood Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

    T-Cell Lymphoma: IPH4102-102
    Sponsor: Innate Pharma
    Study: T-Cell Lymphoma: IPH4102-102
    Cancer stage: Relapsed

    Description: A phase Ib trial evaluating the safety and efficacy of lacutamab in patients with relapse peripheral T-cell lymphoma that express KIR3DL2

    Inclusions: 

    • Patients should have received at least one prior systemic therapy
    • Patients should have had a complete response to first line systemic therapy and / or relapsed or progressed no sooner than 6 months after finishing first line therapy
    • KIR3DL2 expression
    • Presence of at least 1 target lesion

    Exclusions: 

    • Treatment with > 3 lines of systemic therapies prior to enrollment. Consolidation therapy
      including stem cell transplant is not considered a line of therapy

    Prior treatment: 

    • Patients should have received at least one prior systemic therapy

    Purpose: 

    • To Evaluate the safety and efficacy of lacutamab

    Basic qualifications:

  • Melanoma and Skin Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

    Melanoma HuyaBio HBI-8000-303
    Sponsor: HUYA Bioscience International, LLC
    Study: HBI-8000-303
    Cancer stage: Unresectable or Metastatic Melanoma

    Description: Multicenter, Randomized, Double-Blind Phase 3 Study of HBI-8000 Combined with Nivolumab vs. Placebo with Nivolumab in Patients with Unresectable or Metastatic Melanoma Not Previously Treated with PD-1 or PD-L1 Inhibitors (NCT04674683) Melanoma pamphlet

    Inclusions:

    • Diagnosis of non-uveal, Stage III (unresectable), or Stage IV (metastatic) melanoma
    • Known BRAF V600 mutation status or consent to BRAF V600 mutation testing before randomization

    Exclusions:

    • Previous treatment
    • History of a cardiovascular illness
    • Uncontrolled hypertension
    • New, active, or progressive brain metastases

    Prior treatment:

    • No

    Purpose:

    • To compare between Test (HBI-8000 + nivolumab) and Control (placebo + nivolumab)

    Basic qualifications: Same as inclusion

    • Diagnosis of non-uveal, Stage III (unresectable), or Stage IV (metastatic) melanoma
    • Known BRAF V600 mutation status or consent to BRAF V600 mutation testing
  • Pancreatic Cancer

    Pancreatic: PT049
    Sponsor: Xbiotech USA Inc.
    Study: Pancreatic: PT049
    Cancer stage: Advanced Pancreatic Cancer

    Description: A Phase I/II randomized, double-blind, placebo-controlled trial (1-BETTER) examining XB2001 (anti-IL-1? True Human antibody) in combination with ONIVYDE + 5-FU/LV (+folinic acid) in advanced pancreatic cancer

    Inclusions: 

    • pancreatic adenocarcinoma of exocrine pancreas that is metastatic, unresectable, or recurrent

    Exclusions: 

    • Evidence of brain metastases
    • Prior whole brain radiation therapy

    Prior treatment: 

    Purpose: This trial will include 2 portions (phase 1 and phase 2):

    Phase 1:
    • The first portion will be a Phase I, open label, dose escalation study to investigate the safety and tolerability of XB2001 in at least 9 subjects as measured by Dose-Limiting Toxicity (DLT), in combination with ONIVYDE + LV + 5-FU chemotherapy regimen as second or third line treatment in subjects with advanced pancreatic cancer and to determine the recommended dose for the subsequent Phase 2 study.
    • The phase 2 portion will be implemented following the completion of the Phase I portion and declaration of safety with respect to the maximum tolerated dose (MTD) or the maximum dose studied if the MTD is not observed in phase I portion.
    Phase 2:
    • The target enrollment in the phase 2 portion is 60 subjects which will be randomized on a 1:1 basis to XB2001 plus ONIVYDE + LV + 5-FU (Arm 1) or placebo plus ONIVYDE + LV + 5-FU (Arm 2).

    Basic qualifications:

  • Prostate Cancer

    Advanced Malignancies: ARCUS ARC-12
    Sponsor: ARCUS
    Study: Advanced Malignancies: ARCUS ARC-12
    Cancer stage: Advanced

    Description: A phase 1/1b study to evaluate the safety and tolerability of AB308 in combination with AB122 in advanced malignancies

    Inclusions: 

    • Participants may have any pathologically confirmed solid tumor type for which no standard of care therapy exists
    • or pathologically confirmed NHL who are refractory or have relapsed on prior chemotherapy regimen and who have not received or are unable to receive allogenic stem cell transplant (ASCT) or adoptive cell transfer (ACT)
    • Participants may have received up to and including 5 lines of prior systemic anti-cancer therapies for advanced/recurrent and PD (an unlimited number of prior hormonal therapies) is allowed

    Exclusions: 

    • Treatment with systemic immunosuppressive medication
    • Prior treatment with an anti-TIGIT monoclonal antibody

    Prior treatment: 

    • Up to and including 5 lines of prior systemic anti-cancer therapies

    Purpose: 

    • To evaluate the safety, tolerability, PK, pharmacodynamics, and clinical activity of AB308 (anti-TIGIT inhibitor) in combination with zimberelimab (PD-1 inhibitor)

    Basic qualifications: 

  • All Other Cancers

    High risk of Ovarian Cancer Surgical Study: NRG- CC008
    Sponsor: NRG Oncology
    Study: Ovarian Cancer Risk: NRG- CC008
    Cancer stage: None

    Description: A study to compare two surgical procedures in women with BRCA1 mutations to assess reduced risk of Ovarian Cancer  

    Inclusions: 

    • Women 35-50 years of age, inclusive
    • At least one intact ovary and fallopian tube

    Exclusions: 

    • A history of any prior cancer and received chemotherapy within the past 12 months
    • hormonal therapy in the past 90 days
    • or radiotherapy to abdomen or pelvis at any prior time                                                                                                                                                        

    Prior treatment: 

    • No prior treatment within the past 12 months

    Purpose: 

    • A study to compare two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) in women with BRCA1 mutations to assess reduced risk of Ovarian Cancer

    Basic qualifications: 

    • Women 35-50 years of age with a high risk of ovarian cancer with at least one intact ovary and fallopian tube undergoing surgery
  • Treatment Related Side Effects

    WST-PZP-005 for peripheral neuropathy
    Sponsor: Winsantor
    Study: WST-PZP-005
    Cancer stage: Stage 3 or 4

    Description: A randomized, double-blind, placebo-controlled, phase 2a study of topical Pirenzepine (WST-057) or placebo for the prevention of dose limiting chemotherapy induced peripheral neuropathy in oncology patients administered Carboplatin and Paclitaxel.

    Inclusions: 

    • Patients scheduled to undergo chemotherapy for an advanced or metastatic (stage 3 or 4) solid tumor with carboplatin and paclitaxel for 6 cycles of treatment.

    Exclusions: 

    • Pre-existing history of peripheral neuropathy due to any cause other than prior chemotherapy

    Prior treatment: 

    • Allowed

    Purpose: 

    • Evaluate the efficacy of once-daily topical dosing of WST-057 by assessing intrasubject change from baseline in function using the patient reported outcomes- FACT/GOG-Ntx 13, neurotoxicity subscale and the PROMIS Physical Function Score.

    Basic qualifications: 

    • Patients starting treatment with Carboplatin and Paclitaxel

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  • Five ways to go green at home

    04/14/2023

    When it comes to boosting your friendly factor with the environment, small changes in everyday habits can make a big difference. Simple swaps from plastic to paper or reduce-reuse-recycle routines can go a long way toward creating a healthier space at home for you and your family.

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